As one of the most optically accessible structures in humans, the eye provides crucial insights into various diseases, including myopia, glaucoma, and systemic conditions like neurodegenerative disorders. Our research utilizes interdisciplinary approaches to develop cutting-edge imaging methods for in vivo study of the eye and brain, which can be categorized into three primary areas:
Fluorescence microscopy offers high specificity and enables quantitative measurement of neurovascular functions in the eyes and brains of small animals. This approach is an indispensable component of our research to shed light on the pathology of ocular and brain diseases using animal disease models.
The photoreceptors in the human retina are capable of absorbing two photons of the same wavelength simultaneously to create a visual sensation, named "two-photon vision". This sensation matches the appearance of light at approximately half the original wavelength. For instance, the absorption of two infrared photons can generate a visual sensation of green light. Because longer wavelengths (like infrared) are more resistant to scattering, they have the potential to provide alternative vision for individuals with certain eye conditions, such as cataracts. Additionally, light perceived through two-photon vision exhibits higher contrast than conventional single-photon vision, offering unique opportunities to develop modern display technologies based on the two-photon vision principle.
Label-free modalities are ideal for clinical imaging as they do not require exogenous contrast agents, resulting in low chemical and phototoxicity. Our most recent effort involves the development of low-cost optical coherence tomography (OCT) devices to measure the axial eye length and track myopia progression in pediatric patients, through inverse problem solving or machine learning.
We use cookies to analyze website traffic and optimize your website experience. By accepting our use of cookies, your data will be aggregated with all other user data.